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Abstract

Controlling Acute Inflammation with Dexamethasone in a Sustained Release Hydrogel Formulation

Rihan Ulla Khan*, Shailesh Gupta, Avinash Kondalkar

Department of Pharmaceutics, NRI College of Pharmacy, Bhopal, Madhya Pradesh

ABSTRACT

Dexamethasone is a potent candidate for hydrogel preparation for topical dosages form because it has metabolis by first pass metabolismand has 10% of dexamethasone is protein bound these factors promote researchers to choose this drug for the formulation of controlled release formulation which maintain adequate concentration inside body. The objective of this study was to formulate and evaluate hydrogels containing dexamethasone as a drug substance in combination with suitable co-solvents and preservatives. Preparad dexamethasone hydrogel by optimizing the ratio between carbopol and triethylamine and good quality maintained good quality of physiochemical parameter like pH, drug content, viscocity, , % entrapment, in vitro release behavior of hydrogel by franz diffusion cell. Release profile of dexamethasone was fit into release kinetic models to determine the mechanism of drug release and it was observed that the release was zero order system. The developed hydrogel was therapeutically efficient, stable and in-vitro release for 8 hour was observed.

Keywords: Dexamethasone, hydrogels, carbopol and triethylamine.


[Full Text Article]