Abstract

EFFECT OF CURCUMIN IN CELECOXIB AND STREPTOZOTOCIN INDUCED EXPERIMENTAL DEMENTIA OF ALZHEIMER`S DISEASE IN MICE

Divya Pathak*, Harlokesh Narayan Yadav, Jeetendra Kumar Gupta

Institute of Pharmaceutical Research, GLA, University, Mathura (U.P)

ABSTRACT

To investigate the effect of Curcumin in Celecoxib and STZ induced experimental dementia of Alzheimer disease in mice. Celecoxib and STZ for administrations were used to induce experimental dementia. Curcumin (150 mg/kg, p.o) treatment started two days prior to Celecoxib or STZ administration followed by treatment of Celecoxib (100mg/kg, p.o) and STZ (3mg/kg, i.c.v). Cognitive behaviour was asses by using Morris water maze and elevated plus-maze was used for by measuring transfer latency (TL). On 9th day animals were sacrificed and acetyl cholinesterase activity was measured to assess cholinergic activity of the brain,thiobarbituric acid reactive species (TBARS) levels, catalase activity, DPPH assay and reduced glutathione (GSH) levels were measured to asses the oxidative stress in brain. The present data demonstrate that curcumin improves memory in celecoxib or STZ induced dementia. From the present data it may be concluded improvement of memory by treatment of Curcumin is due to decrease the oxidative stress.

Keywords: Morris water maze, elevate plus maze, oxidative stress, acetyl-cholinesterase activity, TBARS, DPPH, GSH, Alzheimer`s disease.