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Abstract

A Reviw on Lamotrigine: On Psychosis Disease

Akanksha Singh*, Rahul Mishra

Department of Pharmacology, Rajiv Academy of Pharmacy, Mathura, Uttar Pradesh.

ABSTRACT

Psychosis (from the Ancient Greek "psyche", for mind/soul, and ―-osis", for abnormal condition) means abnormal condition of the mind, and is a generic psychiatric term for a mental state often described as involving a "loss of contact with reality". Psychosis has been traditionally linked to the neurotransmitter dopamine. In particular, the dopamine hypothesis of psychosis has been influential and states that psychosis results from an over activity of dopamine function in the brain,particularly in the mesolimbic pathway. The two major sources of evidence given to support this theory are that dopamine receptor D2 blocking drugs (i.e., antipsychotics) tend to reduce the intensity of psychotic symptoms. Lamotrigine, is anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs. Early studies of lamotrigine's mechanism of action examined its effects on the release of endogenous amino acids from rat cerebral cortex slices in vitro. These studies suggested that lamotrigine acts presynaptically on voltage-gated sodium channels to decrease glutamate release.

Keywords: Psycosis, Lamotrigine, Amphetamine.


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