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Abstract

SPECTROPHOTOMETRIC AND VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF RETINOD DRUG TAZAROTENE IN GEL FORMULATION

Deepak Rawat1*, Avalani Gunjan1, Mahesh Gupta1, Sandeep Singh1, Aashish Pathak2

1. Kota College of Pharmacy, Kota, Rajasthan
2. Sapience Bio Analytical Research Lab, Bhopal, Madhya Pradesh

ABSTRACT

The retinoid are classes of chemical compounds that are related chemically to vitamin a Retinoid are used in medicine, primarily due to the way they regulate epithelial cell growth. Tazarotene is chemically Ethyl6-[2-(4,4- dimethylthiochroman-6-yl) ethynyl] Nicotinate. Tazarotene is a synthetic acetylenic retinoid that is applied topically. It is de-esterified in the skin to its active form, tazarotene acid, which affects cell proliferation and differentiation by modulating gene expression in acne and psoriasis.

Keywords: Retinoid, Nicotinate, , tazarotene acid, RP-Hplc


[Full Text Article]