Login

Journal Front Page

News & Events

  • Call for article for April 2024 issue
  • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
  • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
  • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
  • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
  • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

Formulation and Optimization of Candesartan Loaded Eudragit Coated Microspheres

Amit Sharma*1, Swati Dikshit1, Niraj Upamanyu1, Subhendu S. Mishra2, Ashish Pathak2

1. Department of Pharmaceutics, R.K.D.F College of Pharmacy, Bhopal, M.P., India.

2. Department of Pharmaceutics, Radharaman College of Pharmacy, Bhopal, M.P., India.
3. Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India

ABSTRACT

The objective of present study is enhancement in the oral bioavailability of Candesartan using a lipid-based formulation i.e Eudragit S-100 microspheres. Candesartan is therapeutically a potent antihypertensive agent but it suffers a major drawback of poor oral bioavailability, which is estimated to be 15% due to low solubility in gastrointestinal fluid, hepatic first pass metabolism. The main emphasis of present study is on the use of new approach of lipid-based formulation to enhance the bioavailability of poorly water-soluble but highly permeable drug. The proposed formulation is aimed to enhance the bioavailability of Candesartan by using microspheres coated with eudragit S-100 polymer, which are transported through lymphatic system, thereby preventing hepatic first pass metabolism. Eudragit based microspheres were prepared by oil-in-oil solvent evaporation method using different drug- polymer ratios (1:1 to 1:4), stirring speeds (500-1500 rpm) and emulsifier concentrations (0.5%-1.25% wt/vol). Differential scanning calorimetry, study of the physical mixtures of drug and polymer revealed no drug-polymer interaction. All formulations were evaluated for particle size and shape, swell ability and percentage drug entrapment. The yield of preparation and the encapsulation efficiencies were high for all Eudragit microspheres. The in vitro drug release study of optimized formulation was also performed in simulated gastrointestinal fluids (SGF). The release profile of Candesartan from Eudragit microspheres was pH dependent.

Keywords: Eudragit S 100, Colon specific drug delivery, Microspheres, Candesartan.


[Full Text Article]