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Abstract

Ion-association Methods For The Determination of Mirtazapine in Pure and Pharmaceutical Formulations

Murthy Ch.V.R1,Acharyulu M.L.N *2,Jagannadharao V3, Reddy T.S4,Rama Lakshmi C.S5

1.Department of Chemical Engineering, AU College of Engineering (A),Andhra University, Visakhapatnam-530003 Andhra Pradesh (India).

2. Department of AS&H, VITAM College of Engineering, Mindivanipalem Anandapuram Mandal, Visakhapatnam, A.P , India.
3. Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP) India.
4. DLR College (Degree & P.G COURSES), Gollalamamidada, E.G. Dtt. A.P,533344.
5. C.S.R. Lakshmi, Asst. professor, Nargund College of Pharmacy, Bansankari 3rd stage, Bangalore-85,Karnataka,India

ABSTRACT

Two simple and sensitive extractive visible spectrophotometric methods (A and B) for the assay of Mirtazapine in pure and pharmaceutical Formulations based on the formation of colored chloroform soluble ion-association associates under specified experimental conditions are described. Two dyes namely acidic dye Tropaeoline ooo (TPooo, method A), Azocarmine-G (ACG, method B) are utilized. The extracts of the ion-associates exhibit absorption maxima at 480nm and 540nm for methods A and B respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (1-3) μg/ml for method A, (2-10) μg/ml for method B respectively. The proposed methods are applied to commercial available formulations and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the Mirtazapine in the presence of other ingredients that are usually present in formulations. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost without the need for expensive instrumentation and reagents.

Keywords: Anti fungal, Azocarmine-G (ACG), Assay, Ion-Association methods, Statistical analysis, Tropaeolineooo(TPOOO)


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