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Abstract

SYNTHESIS AND CHARACTERIZATION OF MOLYBDENUM COMPLEX OF GLIMEPIRIDE, AN ORAL ANTIDIABETIC DRUG.

Sibi Jose1*, S.A. Iqbal 2, Ashish Pathak3

1. Department of Chemistry, Sadhu Vaswani College, Bairagarh, Bhopal-462001

2. Crescent College of Technology, Nabibagh, Bhopal-462 038
3. Ravishankar College of Pharmacy, Karond, Bhopal-462010 (India).
 

ABSTRACT

The synthesis and characterization of molybdenum complex with glimepiride (an oral antidiabetic drug) has been studied. The conductometric titration using monovariation method indicates that complex is nonionic and of ML2 type. Analytical data agrees with the molecular formula (C24H34N4O5S)2 Mo.2H2O. Structure of the complex was assigned as octahedral in which ligand molecules lies horizontally joining the central molybdenum atom and one water molecule, each attached vertically with the metal. Infrared, Mass spectral and X-ray studies confirm the co-ordination of sulphonyloxygen on one side and enolic oxygen attached from other side with the metal ion. The structure for complex was proposed on the basis of analytical data and Elemental analysis.

Keywords: Synthesis; Characterization, Glimepiride-metal ion complex, Infrared spectroscopy.


[Full Text Article]