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Abstract

Direct spectrophotometric determination of 5-nitroimidazoles - A review

G V S R Pavan Kumar*, B Sreerama Murty, K T V S Sai Kumar

Department of Chemical Engineering, Maharaj Vijayaram Gajapathiraj College of
Engineering, Chintalavalasa, Vizianagaram 535005 (AP)

ABSTRACT

Nitroimidazoles, classified as anti parasitic drugs, have wide spread applications in their action against various microbial infections in humans. For the quantitative determination of these drugs, various methods are found in literature, which include UV-VIS, HPLC etc. Recently a direct spectrophotometric method was developed and reported in literature for the detection and determination of 5-nitroimidazoles in pure form as well in pharmaceutical formulations in the form of tablets. The method reported was based on the formation of a reddish-purple colour dye, due to the diazotization reaction between the nitro group of drug sample solution with sulphanilamide and NEDA. The drug sample was dissolved in hot water followed by the addition of 2ml each of 0.5% sulphanilamide and 0.3% NEDA solutios. It exhibited a stable instantaneous reddish purple, colour which showed maximum absorbance at 540nm. It was found that all the drug samples under study have shown the same colour with the specified reagents. It was reported to be convenient over earlier methods involving a two step reaction namely reduction followed by diazotization, which can be detrimental to LOD and accuracy.

Keywords: Nitroimidazole, 5-nitroimidazole, metronidazole, ornidazole, tinidazole, secnidazole, stranidazole and spectrophotometry


[Full Text Article]