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Abstract

LUNG TARGETING OF ANTITUBERCULAR DRUGS BY MICROSPHERE: A REVIEW

Anurag Sharma*, Manish k. Chakradhari, Dilip Agrawal, M.P. Khinchi, Natasha Sharma, M.K. Gupta

Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan

ABSTRACT

Targeted drug delivery system or site-specific drug delivery systems are systems that can deliver the drug selectively to the diseased site, in a specified steady concentration, for a prescribed time. This site specific or targeted delivery combined with delivery at an optimal rate would not only improve the efficacy of a drug but would also reduce the possibility of unwanted toxic side effects of the drug, thus improving the therapeutic index. The lung is an attractive target for drug delivery due to noninvasive administration via inhalation aerosols, avoidance of first-pass metabolism, direct delivery to the site of action for the treatment of respiratory diseases, and the availability of a huge surface area for local drug action and systemic absorption of drug. Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 microns which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs. This review focuses on the current status and explores the potential of microsphere carrier systems in pulmonary drug delivery with special attention to their pharmaceutical aspects.

Keywords: Lung Targeting, Pulmonary Microspheres, Inhalable Microspheres, Antitubercular drug microsphere


[Full Text Article]