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Abstract

A review on Histamine2 receptor antagonist: pharmacological and analytical aspects

Saswata Ku. Parida*, N. P. Jivani, Bimal N. Patel, Akruti S. Khodakiya,
Asit R . Sahu, Sibanarayan Acharya

C. U. Shah College of Pharmacy & Research, Wadhwancity, Surendranagar, Gujarat

ABSTRACT

Histamine is an endogenous substance synthesized, stored and released in mast cells, (which are abundant in the skin, GI, and the respiratory tract), basophils in the blood, and some neurons in the CNS and peripheral NS. Histamine H2-receptor antagonists are a unique class of compounds. Pharmacologically they are characterized as a family by their ability to inhibit the secretion of gastric acid, and kinetically they are classified as a family by their similarity in absorption, distribution and elimination. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. Histamine H2-receptor antagonists, also known as H2-blockers, are used to treat duodenal ulcers and prevent their return. They are also used to treat gastric ulcers and for some conditions, such as Zollinger-Ellison disease, in which the stomach produces too much acid. In over-the-counter (OTC) strengths, these medicines are used to relieve and/or prevent heartburn, acid indigestion, and sour stomach.

Keywords: Histamine H2-receptor, Analytical Methods.


[Full Text Article]