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Abstract

ANTIHYPERTENSIVE DRUGS USED FOR TRANSDERMAL DRUG DELIVERY: A REVIEW

*Ranju Pal1, Ragini Shukla2
 

1. Department of Pharmacy, Barkatullah University, Bhopal, India
2. Peoples Institute of Pharmacy and Research Centre, Bhopal (M.P.) India

ABSTRACT

the mankind. Since it is a chronic disease it necessitates long term treatment. But most of antihypertensive drugs available today showed extensive first pass metabolism and variable bioavailability, more frequent of administration make it is an ideal candidate for transdermal drug delivery systems. Transdermal Drug Delivery Systems enhances the drug permeation through the skin which can be achieved by using chemical enhancers and various solvents. Use of chemical enhancers is limited for its chronic application as it causes irritation at the site of application. Microemulsion or nanoemulsion technique proved to be one of the most promising techniques for enhancement of transdermal permeation of drugs. The present article gives the brief view on different antihypertensive drugs formulated as transdermal patch and transdermal nanoemulsion or microemulsion based formulation and their methodology in detailed to enhance the bioavailability as well as to improve the patient compliance.

Keywords: Transdermal drug delivery, hypertensive drugs, transdermal patch, micoemusion, Nanoemusion.


[Full Text Article]