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Abstract

SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC

Pankaj Kadwe*, Deepak Kumar Basedia, Vivek Thakur, B. K. Dubey

Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.)

ABSTRACT

This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.

Keywords: Avanafil, RP-HPLC, Erectile Dysfunction, Stability-Indicating Method, Linearity, Recovery Studies, Forced Degradation, Pharmaceutical Analysis.


[Full Text Article]