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Abstract

ANALYSIS OF ANTI HYPERLIPIDEMIC ACTIVITY OF FAGONIA ARABICA WHOLE PLANT EXTRACT

N Rukesh Gujare*, Monika Parmar, Satkar Prasad

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

One of the most prevalent medical conditions is obesity, which is linked to abnormal blood lipid and lipoprotein levels is hyperlipidemia. But toxicological issues continue to be the main concern with anti hyperlipedemic medication. In this situation nature has potential to treat diseases without exhibiting any side effects. Thus, this study aims at assessing anti-hyperlipedemic activity of F. arabica. The plant material was collected subjected to extraction and qualitative, quantitative analysis was carried out. Further In vivo study was also conduceted. Results revealed that the % yield for pet ether & ethanolic extract was observed to be 5.7%& 10.5% respectively. The phytochemical test revealed the presence of flavonoid, phenol, protein, carbohydrate, saponin & tannin respectively. The total phenolic & flavonoid content was found to be 1.02& 0.56 mg/100mg respectively. Further effects of different treatments on food intake of diet-induced hyperlipidimic rats were analyzed. On the day 7th it was seen that for rats treated with EEFA 200mg/kg & 300mg/kg daily food intake was reduced to 22.47±0.15 g & 20.65±0.22 g respectively. The TC content was reduced to 203.56±6.54 mg/dL for rats treated with treated with EEFA 300mg/kg. Further the triglyceride content was also found to be reduced to 130.51±4.11 mg/dL. While in case of atorvastatin treated rats the triglyceride content was found to be 161.99±0.24 mg/dL. The HDL & LDL was estimated to be 61.99±3.33 & 116.46±6.11 respectively in EEFA 300mg/kg. The VLDL was found to be 27.10±1.04 mg/dL. The rats treated with EEFA 300mg/kg observed to have 8.51±0.12 mg/g fecal cholesterol excreted while fecal bile bile acid was seen to excrete in amount 3.94±0.10 mg/g. From results it can be concluded that F. arabica can be used as an adjuvant in current therapy for the treatment of hyperlipidemia or as a medicinal agent with antihyperlipidemic properties.

Keywords: Hyperlipedemia, Medicinal plants, Phytochemicals, F.arabica, HDL, LDL, VLDL, TG.


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