Abstract

FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE MICROBALLOONS OF AMIODARONE HYDROCHLORIDE

Narendra Kumar*, Deepak Tripathi, Muraree Lal, Avinash Krishnrao Kondalkar

Sun Institute of Pharmaceutical Education & Research (SIPER), Lahar

ABSTRACT

Cardiac arrhythmic disorders which is present 1.5% to 5% of the population overall can lead to lethal cardiovascular diseases. Anti-arrhythmic medication amiodarone, a benzofuran derivative, is frequently employed in a number of contexts. But as it has very short half-life there is need to design a novel drug delivery system. Thus, this study aims at formulating & evaluating microballons of Amiodarone. The formualtion & evaluation of microballon was performed according to standard protocol. In total 6 formulations of microballons were made and evaluated for various parameters. Results showed that the percentage yield was found to be varied from 65.52±0.15 for F1 to 74.45±0.15% for F5. The highest drug was found to be entrapped in F5 formulation which is 75.65±0.17%. The floating time was found to be ranged from 52 seconds to 69 seconds while the percentage Buoyancy spananed from 63.32 to 79.98%. The results of measurement of mean particle size of optimized formulation F5 of floating microballoons was found to be 220.36 nm. The zeta potential value obtained for the optimized Formulation F5 of floating microballoons was -37.12 mV. After examining drug release data from F1 to F6 formualtions the highest % of Drug Release was with the F5 formulation which is 99.74 in 12 hours. The R2 value obtained for Zero order was 0.994 thus it is clear that the floating microballoons of Amiodarone follows zero order release kinetics. Results of stability studies indicated no significant difference in the drug content between initial and formulations stored at 40±2°c & 75±5% RH for 3 months. So, it can be concluded that microballoons may prove to be a useful method of delivering Amiodarone because they increase bioavailability in contrast to traditional dose forms.

Keywords: Microballoons, Amiodaron, Gastroretentive, Novel drug delivery system, Cardiac arrhythmic disorders