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Abstract

FORMULATION AND EVALUATION OF FAMOTIDINE SUSTAINED RELEASE TABLETS CONTAINING CHAMOMILE MUCILAGE

Deepak Kumar Yadav*, Satkar Prasad

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

GERD is common in Western countries, with prevalence ranging from 13% to 20% in the United States and 9.8% to 18% in Europe, while it is lower in Asia (2.5-4.8%). Traditional pharmacological therapy necessitates the administration of therapeutic substances on a regular basis. Sustained Release suitable for overcoming pharmacological side effects and increasing therapeutic efficacy. Thus merging the advantages of sustained release tablet & natural polymer, this study deals with formulation and evaluation of famotidine sustained release tablets containing chamomile mucilage. The formulation & evaluation of tablet was performed according to standard protocol. Results showed that, in total nine formulations the bulk density varied from 0.315 to 0.341 gm/ml while the tapped density ranged from 0.432 to 0.465 gm/ml. The compressibility index spans from 24.330 to 27.742. Further the Hausner ratio extends from 1.325 to 1.384. From the results of post compression parameter it was seen that the maximum drug content was found to be 99.45 % in F7 formulation. The total floating time was greater than 12 hrs for all formulations. The thickness varied from 3.09 to 3.26 mm while the hardness ranged from 6.3 to 6.9 kg/cm2. The weight variation was seen in between 296 to 305 mg while the friability ranged from 0.745 to 0.895%. Further the floating lag time was found to be lowest for F7 which is 25±2 sec while highest for F1 which is 55±3 seconds. The In-vitro drug release study of FGR tablets proved that about 99.74 % drug is released in 12 hrs. The formulated tablet follows peppas model of drug release kinetics which is evident from R² value of 0.952. Thus, formulation F7 have all the ideal parameters & hence can be used for treating GERD.

Keywords: Gastroesophageal reflux disease. Famotidine, sustained release tablets, chamomile, mucilage, Natural polysaccharide.


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