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Abstract

An Experimental Study of Analgesic Activity of Selected Drugs in Comparison with Conventional NSAIDS

Sireesha Kalva*, Ramyasree Yenni

Department of Pharmacology, Sri Venkateshwara college of Pharmacy, Osmania University Madhapur.

ABSTRACT

Pain is an unpleasant sensation but a protective mechanism of our body. It is the most common medical complaint requiring a visit to a physician. The new non-steroidal anti-inflammatory drugs [NSAIDS] are commonly used. Healthy adult Swiss albino rats are used as experimental animals. The analgesic activity of the selected drugs were evaluated using eddy hot plate method. Rats weighing 200-250gm of either sex were divided into 6 groups. Oral diclofenac is used as standard and water for injection is used as control. Etoricoxib, Atorvastatin, Triphala and Aloe Vera are used as test drugs. The present study was conducted to evaluate and compare the anti-nociceptive activity of different selected drugs with conventional NSAIDS diclofenac in a hot model of acute pain using hot plate tests. In comparison with control group [vehicle] diclofenac showed significant increase in the reaction time at various time periods in the hot plate tests. In the hot plate model, the test drugs [etrocoxib, atorvastatin, Triphala and aloe Vera] showed a significant increase in the reaction time in comparison to control group. Our study concludes that various drugs selected etoricoxib, atorvastatin, triphala and aloe Vera have therapeutic potential for treating pain disorders and is non inferior to standard drug- Diclofenac.

Keywords: Analgesic activity, eddy’s hot plate, albino rats, Diclofenac sodium, Etoricoxib.


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