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Abstract

FORMULATION & EVALUATION OF PHYTOSOME OF PRUNELLA VULGARIS FOR ANTI DIABETIC ACTIVITY

Doli Kumari Singh*, Sachin K. Jain

Oriental College of Pharmacy and Research, Oriental University, Indore (M.P.)

ABSTRACT

Diabetes mellitus is a set of disorders that cause hyperglycemia and glucose intolerance as a result of a lack of insulin, defective insulin function, or both. Diabetes can further give rise to other diseases. So, the aim of this study is the formulation of phytosome by use of bioactive constituent of prunella vulgaris and its evaluation for anti diabetic effect. The plant material was obtained and subjected to extraction. Further the qualitative & quantitative estimation of phytochemicals was performed. The phytosomes were formulated & evaluated for every parameter along with anti diabetic activity. The results showed that the percentage yield of hydroalcoholic extract of Prunella vulgaris exhibited higher yield 7.56% followed by pet. ether extract of 2.78%. The total phenolic and flavonoid contents of Prunella vulgaris showed the content value 0.475mg GAE/100mg extract and 0.846mg QAE/100mg extract respectively. The entrapment efficiency of the phytosomes was found in the range of 65.52 to 75.65%. Particle size of all formulations found within range 236.65-365.45nm. Formulation F10 was found best. The IC 50 value for phytosome by alpha amylase assay was found to be 231.22 (μg/ml). The first order was found to be maximum that is 0.988 hence indicating drug release from formulations was found to follow First Order release kinetics. Results of stability studies clearly indicates that optimized batches of phytosomes were stable over the chosen temperature and humidity conditions up to 3 months as were found no significant variation in physical appearance and % drug content. Thus, it can be concluded that formulated F10 phytosome exhibits all ideal characteristics & can be used to treat diabetes.

Keywords: Anti diabetic, Herbal Medicine, Phytosome, Prunella vulgaris.


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