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Abstract

PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING OF ENTADA PHASEOLOIDES SEED EXTRACT FOR THE TREATMENT OF ACNE

Deeksha Gupta*, Sandra Gautam, Deepak Kumar Basedia, B. K. Dubey

Technocrats Institute of Technology, Pharmacy, Bhopal (M.P.)

ABSTRACT

The most prevalent skin condition affecting adolescents is acne vulgaris. Seborrheic skin, comedones and blackheads, papules, pimples, and scars are the hallmarks of acne vulgaris. These symptoms can cause loss of self-esteem leading to depression. There are many different synthetic drug treatments plans available for acne vulgaris but none of these regimens is without risks. Compared to modern therapies, herbal cures typically have fewer adverse effects. E. phaseoloides a member of the Fabaceae family has a long history of use in Indian traditional medicine, where it is used to treat a variety of conditions including brain haemorrhage and as an emetic, anti-irritant, promoter of hair growth, and painkiller. This study deals with analysing anti acne potential of seeds of E. phaseoloides. Plant material was collected & subjected to extraction. All other In vitro & In vivo procedures are then performed according to standard protocol. Results revealed that yield was found to be (6.47% w/w of crude drug) of hydroalcoholic extract. The phytochemical screening of Entada phaseoloides showed the presence of various classes of secondary metabolites, including alkaloids, flavonoids, saponins, tannins, terpenoids, and glycosides. The total phenolic & flavonoid content was found to be 0.536mg GAE/100mg of dry weight & 0.764mg QE/100mg of dry weight. The zone of inhibition for P.acne was found to be 18±0.57mm for 100mg/ml of dried extract. While for E. coli it was found to be 16±0.74mm. In case of A. flavus the zone of inhibition was found to be 8±0.86mm. Rats showed that both Clindamycin and hydroalcoholic extract of Entada phaseoloides were effective in reducing the severity of acne induced by Propionibacterium acnes. However, Clindamycin was found to be more effective in reducing the number of inflammatory cells in the affected skin, while Entada phaseoloides extract was found to be more effective in reducing the size of the lesions. From the results it can be concluded that seeds of E. phaseoloides possess appreciable anti acne activity.

Keywords: Medicinal plants, Herbal medicines Anti acne, Acne vulgaris, Entada phaseoloides, P.acne.


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