Abstract

FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING ORAL WAFERS OF RIZATRIPTAN

Deepshikha Prasad*, Eisha Ganju, Bhaskar Kumar Gupta

School of pharmacy and research, Peoples University, Bhopal (M.P.)

ABSTRACT

Migraine is a major global health issue that affects over 10% of the population and is the second leading cause of years lived with disability worldwide. Hours or days can pass between migraine attacks, and they typically happen once a month on average Wafers are practical alternative to oral tablets for patients who have difficulty swallowing tablets or have no liquids available at the onset of an attack. Thus, this study aims at developing Fast Dissolving Oral Wafers of Rizatriptan. Oral wafers were prepared by standard methods. The thickness of formulated Rizatriptan was varied between 75±4 μm to 86±3 μm. The formulated. The wafers showed a weight variation between 98±6mg - 124±3 mg. The pH of the formulated wafers was found to be in the range of 6.2±0.2-6.9±0.1. The moisture content of the formulated wafers was found to be in the range of 1.25±0.25 - 1.85±0.14. Thus, it can be considered that the formulation F7 of the Rizatriptan showed minimum moisture content among all formulations. The percentage drug content was between 96.64±0.32% and 99.45±0.18%. The formulated Rizatriptan wafers showed a disintegration time in the range of 8±2-20±5sec (as shown in Table 8.3). Formulation F7 showed the least disintegration time of 8±2 sec. Thus, from results it can be concluded that the formulated oral wafer of Rizatriptan have all ideal properties & can be used as instant remedy to control headache.

Keywords: Fast Dissolving, orally disintegrating Wafers, Rizatriptan, Migraine.