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Abstract

FORMULATION & EVALUATION OF LINAGLIPTIN LOADED ETHOSOMES FOR TREATMENT OF DIABETES

Meenakshi Khatarkar*, Vinod Kumar Dhote, Rajesh Singh Pawar

Truba Institute of Pharmacy, Bhopal (M.P.)

ABSTRACT

Diabetes mellitus, one of the most prevalent chronic diseases, is an endocrine and metabolic condition characterised by hyperglycemia and a number of consequences. However, there is still no comprehensive treatment plan for managing diabetes mellitus due to inherent drug deficiencies and restrictions on delivery methods. Ethosomes are non-invasive delivery systems, to deep skin layers and/or the systemic circulation. This study attempts to investigate linagliptin entrapped ethosomes for treatment of diabetes. Ethosomes were prepared as per standard methods & evaluated for various parameters. Results showed that the entrapment efficiency for F4 formulation was found to be 79.85±0.41 and vesicle size was found to be 105.65±0.22nm. The zeta potential for F4 was observed to be -38.5. Commutative % drug release was also found to increase with time. Regression analysis data follows Peppa’s plot. The initial burst release was due to the unbound drug being released from the ethosomes. The release profile of formulation F4 was much better than that of the other formulations tested Overall, the in vitro drug release data for optimized ethosomal formulation F4 showed a sustained release profile. This indicates that formulation F4 could be a suitable option for topical delivery of anti-diabetic drugs.

Keywords: Ethsosmes, Diabetes, Linagliptin, Anti-diabetic drugs, vesicular drug delivery system


[Full Text Article]