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Abstract

EXTRACTION, PHYTOCHEMICAL INVESTIGATION AND ANTI ACNE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF WRIGHTIA TINCTORIA

Shivansh Tiwari*, Satkar Prasad

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

Acne vulgaris is a common skin disorder affecting more than 85% of teenagers in the United States. While it is not a lethal or debilitating disorder, it can be painful and disfiguring, causing significant physiological distress, and heavy economic burden. Acne is associated with increases in anxiety, depression, and suicidal ideation. Wrightia tinctoria R.Br. (Apocyanaceae) is known as a biologically effective plant for the treatment of jaundice in the Indian traditional system of medicine. It is a wild medicinal tree possessing anti-inflammatory, antidiabetic, antinociceptive, hepatoprotective, antibacterial, antifungal, antiviral, antipsoriatic, anticancerous, anthelmintic, aphrodisiac, analgesic, and antipyretic activities. So aim of present work to evaluate anti-acne activity of Wrightia tinctoria using suitable animal model. The acne like inflammatory activity was carried out by measuring the ear thickness. Hydroalcoholic extract of Wrightia tinctoria (HEWT) showed significant reduction in the ear thickness. It seems that the increased ear thickness and inflammation caused due to various biochemical, viz. various kinins, histamine and 5- HT is significantly reduced.

Keywords: Wrightia tinctoria, Hydroalcoholic extract, Anti acne, Hydroalcoholic extact.


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