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Abstract

Preparation of Topical Gel and Cream Formulations containing Lavender and Tea Tree Essential Oils and Evaluation of their Antimicrobial Activity

A.P. Indulkar1, S. Sawant2, J.S. Lobo2, R. Birmole2, S. Patade2*

1Humera Khan College of Pharmacy, Mumbai 400102
2Department of Microbiology, Wilson College, Mumbai 400007

ABSTRACT

Skin infections are among the most commonly occurring infections and hence effective topical formulations are continuously in demand. Often, these infections present therapeutic challenges to medical practitioners due to the growing concerns regarding multidrug-resistant pathogens. Keeping this in mind, the objectives of the current study were to formulate topical cream and gel containing essential oils of lavender and tea tree, and to study their antibacterial activity. Various batches of formulations were prepared in our study and evaluated for their organoleptic characteristics and physicochemical properties. The Minimum Inhibitory and Bactericidal Concentrations (i.e., MIC and MBC) of essential oils were determined by broth dilution method and viable count assay respectively. The MICs of lavender and tea tree oil were found to be 4% and 0.2%, and the MBCs were 3% and 0.1% respectively. Various topical formulations with 4% lavender oil and 0.2% tea tree oil were prepared and the one showing best pharmaceutical and physicochemical characteristics was further subjected to antibacterial assay. The batches C6 and C3C of cream and gel formulations respectively exhibited considerable antibacterial activity as observed by the zones of inhibition obtained in the range of 13-19mm.

Keywords: Cream, Formulation, Gel, Lavender oil, MBC, MIC, Tea Tree oil.


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