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Abstract

EXTRACTION, PHYTOCHEMICAL INVESTIGATION AND STUDY OF ANTIHYPERLIPIDEMIC POTENTIAL OF LEAVES EXTRACT OF ADIANTUM LUNULATUM

Surya Prakash, Sailesh Kumar Ghatuary, Satkar Prasad, Monika Parmar

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

Secondary metabolites produced by plant responsible for the prevention and curing of various diseases and show microbicidal activity, these secondary metabolites are produced as a part of primary metabolic pathway. The aim of this study was to investigate the possible antihyperlipidemic effect of Adiantum lunulatum leaf extract in triton induced hyperlipidemic rats. In the present study, we have investigated the effect of Adiantum lunulatum (Leaves extracts) against experimentally induced hyperlipidemia in rats. The extracts at the dose of 300mg/kg, p.o. significantly reduced serum TC and TG levels. Additionally, this decrease in TC levels corresponded significantly to a reduction in LDL-C levels. These findings were supported by a decrease in atherogenic index and an increase in the HDL-C/LDL-C ratio. Since Diet-induced hyperlipidemia is mainly due to inhibition of the extractable (heparin releasable) pool of lipoprotein lipase, the serum TG-lowering effects can be attributed to the activation of lipoprotein lipase. It is reported that cholesterol homeostasis is maintained by the control of two processes, viz., and cholesterol biosynthesis, in which HMG-CoA reeducates catalyzes the rate-limiting process, and cholesterol absorption of both dietary cholesterol and cholesterol cleared from the liver through biliary secretion.

Keywords: Adiantum lunulatum, Phytochemical investigation, Antihyperlipidemic potential.


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