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Abstract

FORMULATION AND EVALUATION OF MOXIFLOXACIN BIOADHESIVE TABLETS

Kanika Dhote, Vinod Dhote*

Truba Institute of Pharmacy, Bhopal

ABSTRACT

Gastroretentive Moxifloxacin floating tablets for the eradication of Helicobacter pylori (H. pylori) were prepared using the matrix forming polymer hydroxypropyl methylcellulose (HPMC K15M), in different ratios by wet granulation method. Buoyancy of formulated tablets was achieved by an addition of an effervescent mixture consisting of sodium bicarbonate to some formulations. The prepared floating tablets were characterize for weight variation, thickness, friability, hardness, drug content, in vitro buoyancy, water uptake and in vitro release. The prepared floating tablets revealed satisfactory physicochemical characteristics. Incorporation of gas-generating agent improved the floating parameters. HPMC K15M floating tablet formulation (CF1) offered the best controlled drug release (>8 h) along with floating lag time 24 h. The value of (n) in case of CF1 (n = 0.37) revealed a Fickian diffusion mechanism of formulated floating tablets.

Keywords: Gastroretentive, floating tablets, H. pylori, I , Fickian diffusion, Moxifloxacin.


[Full Text Article]