Abstract

PHYTOPHARMACOLOGICAL SCREENING OF ROSA INDICA (FLOWER) FOR GASTRIC ULCER ACTIVITY

Md Fahim, Kanika Dhote*, Vinod Dhote, Surendra Jain

Department of pharmacology, Truba institute of Pharmacy, Karond – Gandhi Nagar Bypass Bhopal-462038

ABSTRACT

Medicinal Plants have been played an important role as a resource of natural medicines for human health, from the long period of time. Rosa indica, a woody perennial flowering plant is used in the treatment of diarrhoea, asthma, leukoderma and inflammation of mouth. The present study was carried out to evaluate the anti-ulcer activity of methanolic extract of the leaves of Rosa indica in ethanol induced mucosal damage ulcer models. The crude extract was obtained by soxhlet extraction in methanol. Phytochemical screening showed the presence of the active pharmacological components such as tannins, glycoside, flavonoid, alkaloids, Terpenoids, Phenolic compound, Protein and amino acid in extract. To evaluate the anti-ulcer activity, oral administration of methanol extract of Rosa indica was performed at two different doses 200 and 400 mg/kg that exhibited dose dependent ulcer index when compared to the ulcer control models. Ranitidine (50mg/kg) was used as standard drug which exhibited percent inhibition if 1.831. The present study demonstrated that the crude methanolic extract possessed significant dose dependent anti-ulcer activity.

Keywords: Medicinal Plant, Phytochemical, Rosa indica, Anti-ulcer activity