Abstract

PHYTOPHARMACOLOGICAL SCREENING JUICE OF TRITICUM AESTIVUM AND CURCUMA LONGA LEAVES AGAINST INDOMETHACIN INDUCED PEPTIC ULCER

Imran Hussain, Hargovind Garg*, Rajesh Singh Pawar

Department of Pharmacology, Truba Institute of Pharmacy, Karod- Gandhi Nagar Bypass road, Bhopal-462038 (MP)

ABSTRACT

This study investigated the anti-ulcerogenic activity of juice of Triticum Aestivum and Curcuma Longa leaves against indomethacin-induced peptic ulcer in rats. Thirty-six rats were separated into 6 groups and each groups containing six rats. For 7 days before ulcer induction with indomethacin, group first is normal group received the normal saline 1 ml for 7 days. Group second served as inducer group indomethacin (30 mg/kg) was administered orally. Group third was served as Triticum aestivum (1 mL/kg b/w) group administered orally. Fourth group served as Curcuma longa (1 mL/kg b w). Fifth group was treated with 1:1mL/kg b/w of Triticum aestivum+ Curcuma longa. Sixth group was served as Standard (Omeprazole 20 mg/kg b/w). The animals were sacrificed; their stomachs were removed and examined for ulcer index, volume of gastric juice, pH of gastric juice and free acidity. Fifth group combination of Triticum aestivum + Curcuma longa (1:1 mL/kg b/w) showed the significant result as compared to Triticum aestivum and Curcuma longa individual dose. Thus, from the present study concluded that the combined juice of Triticum aestivum and Curcuma longa stimulate the anti-ulcer activity.

Keywords: Anti-ulcerogenic, Indomethacin, Stimulate and Induction.