Abstract

CURRANT REVIEW ON SYNTHESIS OF PRODRUG AND ITS APPLICATION

Yash Jain, Hiteshi Jain, Yash Soni, Palak Jain, Imran Khan*

Adina Institute of Pharmaceutical Sciences, Sagar (M.P.)

ABSTRACT

Prodrug design is a well-known molecular modification method that tries to increase the solubility and pharmacokinetic aspects of medications while lowering their toxicity by optimizing their physicochemical and pharmacological properties. Carrier would alter the physical properties of a medicine in order to boost its fat or water solubility or to enable site-directed delivery. Despite the fact that multiple studies on diverse prodrugs have been conducted, there have been surprisingly few reviews on different carriers that can be employed for prodrug synthesis published too far. One of the most significant roadblocks to drug development is a lack of solubility. The goal of this review is to describe current developments and application of prodrug approach. The primary chemical carriers will be reviewed, as well as instances of effective techniques, with an emphasis on the field's progress in the last ten years.

Keywords: Prodrug, Synthesis, Application, Review