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Abstract

DEVELOPMENT AND IN VITRO EVALUATION OF FAST DISINTEGRATING TABLET OF MEFENAMIC ACID USING SUBLIMATION TECHNIQUE

Shivangi Sahu, Nisha Thakre*, Dilip Tiwari, Neeta Rai

Lakshmi Narain College of Pharmacy (LNCP), Bhopal (M.P.)

ABSTRACT

The purpose of this research was to improve Fast disintegration time of mefenamic acid tablets by using sublimation methods and determine existence of tablet. Rapid orally disintegrating tablets of mefenamic acid were successfully prepared by direct compression, which is the simplest, and most cost-effective technique to prepare tablets with good physical properties and minimum stability issues, and sublimation technique, using either camphor or menthol as the subliming agent. Further ten batches (TF1-TF10) were prepared by using camphor or menthol,0.1N NaOH, 0.1N HCl and PBS in different All the formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time, wetting time, in vitro dissolution. The percentages of drug dissolved from FDTs TF10 after 20 minutes were 98.98±0.03, indicate that the process used to prepare the FDTs greatly enhanced the extent and rate of dissolution of mefenamic acid.

Keywords: Fast disintegration Tablet, Mefenamic acid, Bioavailability, Sublimation Methods.


[Full Text Article]