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Abstract

FORMULATION & EVALUATION OF ETHOSOMAL PATCH FOR DELIVERY OF METHOXSALENE

Vinod Dhote1*, Kanika Dhote1, Surendra Jain1, Deepti jain2

1Truba Institute of Pharmacy, Bhopal, India
2 SOPS RGPV, Bhopal, India

ABSTRACT

Transdermal drug delivery system minimizes the systemic absorption thereby increases the bioavailability. Methoxsalene is an antiplatlet drug generally avelable in tablet formulation. Oral delivery of Methoxsalene leads to its metabolism by cyp450 resulting in its active metabolite R-130964 and inactive metabolite. All the systems were characterized for vesicle morphology, particle size and entrapment efficiency by Scanning Electron Microscopy, Transmission Electron Microscopy, Differential light scattering and centrifugation respectively. The effect of different formulation variable on skin permeation of Methoxsalene was studied via synthetic semi permeable membrane by using diffusion cell. Methoxsalene entrapped ethosomal vesicles were prepared by hot method.

Keywords: Transdermal drug delivery, ethosomes, Methoxsalene, novel drug delivery system.


[Full Text Article]