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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES OF FENOPROFEN

Murli*, Kaushelendra Mishra, Dr. A. K. Singhai 

Lakshmi Narain College of Pharmacy (LNCP), Bhopal (M.P.)

ABSTRACT

The objective of this study is to prepare and evaluate Fenoprofen transdermal patches by using different combinations of polymer and enhancers as well as compare the efficiency of various enhancers. Transdermal patches composed of different polymers HPMC, Ethyl Cellulose, Eudragit RLPO and Eudragit RSPO. The thickness of the films varied from 85±3 to 105±4 mm. All the patches showed satisfactory folding endurance properties. Folding endurance values of all formulation more than 185 indicating good elasticity and strength. The formulation F2 show lowest moisture content and moisture uptake than other formulation. This is due to because of polymer ratio (like Ethyl Cellulose). If lower moisture content in transdermal patch it be good to prevent the brittleness with 100% dryness and also maintain the stability of formulation. The tensile strength was found to be in the range of 0.891 to 0.995. The formulation Fenoprofen F3 showed the best tensile strength. The In-vitro permeation study was done to see the effect of polymers through the Franz diffusion cell from patch having Eudragit RLPO, RSPO, HPMC, EC in different conc. to optimized formulation for in-vitro study.

Keywords: Fenoprofen, Transdermal patches, Ethyl Cellulose, Eudragit RLPO, Eudragit RSPO, Formulation, Evaluation


[Full Text Article]