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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES OF ANTIPSYCHOTIC DRUG OLANZAPINE

Sailesh Kumar Ghatuary*, Abhishek Kumar, Satkar Prasad, Kalpana Badoniya

RKDF School of Pharmaceutical Science, Bhopal  (M. P.)

ABSTRACT

Olanzapine containing transdermal patch was prepared utilizing solvent casting method. Characterization of transdermal patches carried out by Thickness, Percent moisture content, Percent moisture uptake, Folding endurance, Tensile Strength, Drug Content and In Vitro skin permeation study. In all formulations formulation F4 contain minimum moisture contain 1.52±0.41% and minimum moisture uptake 2.11±0.74%. The maximum folding endurance was found 182±5 in formulation F4. Drug content of the all formulations was determined by dissolving the transdermal patches in methanol followed by centrifugation and then analyze on UV spectrophotometry. The drug content was found more than 90% in all the formulations with slight fluctuation. The drug content analysis of different formulations was done according to the procedure given in section. The drug content ranged between 96.65±0.52 and 99.85±0.41. The percentage drug content of all formulations. The maximum drug content was found in formulation F3, 99.85±0.41%. It was concluded here that the formulation F4 showed better permeability amongst the prepared transdermal matrix type patches for olanzapine.

Keywords: Olanzapine, Transdermal patch, Eudragit RSPO, HPMC, Evaluation, In Vitro skin permeation study.


[Full Text Article]