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Abstract

DEVELOPMENT AND INVITRO EVALUATION OF TRANSFEROSOMAL GEL OF CLOBETASOL PROPIONATE

Aakanksha Swarnkar, Priyanka Namdeo*, Dr. Akhlesh Singhai

Lakshmi Narain College of Pharmacy (LNCP), Bhopal (M.P.)

ABSTRACT

Topical delivery of drug means the application of drug to skin for the localized effect, and in transdermal drug delivery system (TDDS) skin is used as a potential route for the delivery of the systemic action of drugs. Transferosomes are the artificial vesicles and the more distort than the standard liposomes. Transferosomes have been delineate to enhance the transdermal delivery of drugs when applied it directly to the surface of skin nonocclusive. Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, seborrheic dermatitis, contact dermatitis, and psoriasis. The purpose of this paper was to develop and Invitro Evaluation of Transferosomal gel of clobetasol propionate. The prepare transferosome gel containing clobetasol propionate using different concentration of surfactant and phospholipids. Transferosomes were prepared by thin film hydration technique. This technique is much frequently used owing to its simplicity and practicability and its ability to yield small and uniform vesicles with high drug entrapment efficiency. It was found that the in vitro drug release of formulation CT1G2 (95.10±0.09) was best explained by higuchi model as the plot showed the highest linearity, the value of R2 found to be highest for the higuchi model.

Keywords: Clobetasol propionate, Glucocorticoids, Higuchi Model, Skin infection, Transferosome, Thin film hydration Technique.


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