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Abstract

FORMULATION AND EVALUATION OF LULICONAZOLE LOADED INVASOMES GEL

Pawan Singh*1, Dr. Gaurav Jain1, Priyanka Namdev1, Dr. Akhlesh Singhai1

1Lakshmi Narain College of Pharmacy (LNCP), Bhopal (M.P.)
2Scan Research laboratories, Bhopal (M.P.)

ABSTRACT

Superficial fungal infection in immunocompromised patients can lead to many disorders and complications. Currently, new topical treatment options are critically needed to treat these fungal infections. Luliconazole is a topical antifungal medicine used for fungal infection treatment. The purpose of this paper was to develop a new topical luliconazole invasomes incorporated gel. Different formulation prepared for Luliconazole loaded in to invasomes by mechanical dispersion technique. The maximum drug content was found in formulation LG-2 (99.12±0.25) and selected as optimized formulation. When the regression coefficient values were compared, it was observed that ‘r2’ values of higuchi was maximum i.e. 0.995 hence indicating drug release from formulations was found to follow higuchi release kinetic.

Keywords: Luliconazole, Invasomes, fungal infection, in-vitro diffusion study.


[Full Text Article]