Abstract

ANTIOXIDANT AND ANTIPYRETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF HERBAL PLANT ONOSMA BRACTEATUM

Anubhuti Mishra*, Mrs. Sangeeta Mewada, Om Prakash Banshkar, Anjali Chauhan,
Dr. Brijesh Sirohi, Dr. Shailendra Lariya

Radharaman College of Pharmacy, Bhopal (M.P.)

ABSTRACT

This study was carried out to evaluate the antipyretic effects of hydroalcoholic extract of leaves of Onosma bracteatum in rats. The antipyretic potential was done using yeast as pyrexia inducing agent. The findings from the present study were in agreement with other studies on antipyretic potential medicinal plants in animal models. The antipyretic effects of hydroalcoholic extract of leaves of Onosma bracteatum at different dose levels exhibited a dose-independent response on yeast-induced fever in rats. Lower dosages of 100 mg/kg and higher 200 mg/kg body weight were as effective as dose dependent manner. The results of present study indicate that the hydroalcoholic extract of Onosma bracteatum leaves possesses significant antipyretic effect on yeast induced hyperthermia in rats. This may be attributed to the presence of chemical constituents in the extracts which may be involved in inhibition of prostaglandin synthesis. Also, there are several mediators or multiprocessors underlining the pathogenesis of fever. Inhibition of any of these mediators may bring about antipyresis. The hydroalcoholic extract of Onosma bracteatum leaves at the 200 mg/kg body weight was marginally effective than 100 mg/kg body weight dose. These findings suggest a better or a similar prostaglandin synthesis inhibition by the active components in the plant's extracts. There is therefore, a possibility of the plant extracts working effectively by blocking alternative mechanisms during fever inhibition.

Keywords: Onosma bracteatum, leaves extract, Antipyretic effects, hydroalcoholic extract.