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Abstract

DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERE FOR EFFECTIVE TREATMENT OF GASTRIC ULCER

Gyandeep Pandey, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya*

College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Sehore (M.P.)

ABSTRACT

The present study was to prepare and evaluate the floating microspheres of Esomeprazole as a model drug for prolongation of the gastric retention time for oral delivery. Esomeprazole is a proton pump inhibitor which acts by irreversibly blocking the (H+K+)-ATPase enzyme system of the gastric parietal cell. Its half-life is 1-1.5 hrs. Esomeprazole poor absorption may be because of degradation in gastric acid which can be prevented by incorporation of sodium bi carbonate which is a systemic antacid and act as buffer. The Esomeprazole floating microspheres were prepared by double emulsion solvent diffusion method by using Ethyl cellulose and different grades of Eudragit RLPO and RSPO, using Dichloromethane and alcohol solvent systems. The drug entrapment efficacies of different formulations were in range of 63.21±0.36- 75.45±0.14% w/w. The maximum percentage yield, drug entrapment, percentage buoyancy and floating lag time was found to be formulation F3 in floating microsphere. The optimized formulation of both batches subjected to further studies.

Keywords: Esomeprazole, Floating microspheres, Evaluation, RLPO, RSPO.


[Full Text Article]