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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PYRIDOXAMINE DIHYDROCHLORIDE AND ACETYLCYSTEINE IN TABLET DOSAGE FORM.

Sneha Sukadev Ghule*, Ashpak Tamboli, Sagar Kale, Sagar Landage, Snehal Patil

Department of Pharmaceutical Chemistry,
Sahyadri College of Pharmacy, Methwade, Sangola, Solapur, Maharashtra, India-413307

ABSTRACT

The present study describes simple, accurate, precise UV spectrophotometric method for the simultaneous estimation of Pyridoxamine dihydrochloride and Acetylcysteine in tablet dosage form. The method involved measurement of absorbance at two wavelengths 220 nm and 216 nm λmax of Pyridoxamine dihydrochloride and Acetylcysteine. Linearity was observed in the range of 2.5microgram/ml to 12.5microgram/ml (r2=0.997) for Pyridoxamine dihydrochloride and 15microgram/ml to 75microgram/ml (r2=0.999) for Acetylcysteine. The percentange mean recovery was found to be 99.26% for Pyridoxamine dihydrochloride and 100.7 % for Acetylcysteine. The percentage RSD for the recovery study was less than 2. The methods were validated as per ICH guidelines

Keywords: Pyridoxamine dihydrochloride, Acetylcysteine, Simultaneous equation, validation, UV spectrophotometer.


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