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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FLUCONAZOLE HYDROGEL FOR OPTIMUM ANTIFUNGAL TREATMENT

Shubham Badkur*, Dr. Lavakesh Kumar Omray, Dr. Kapil Malviya

Radharaman Institute of Pharmaceutical Science, Bhopal (Madhya Pradesh)

ABSTRACT

The present investigation was prepared topical application of hydrogel containing fluconazole was an attempt to make use of the immense potential of hydrogel as a carrier to improve the permeability. In this research it was to developed and evaluated the Hydrogel containing fluconazole to obtain the optimized formulation which favorable for application as skin delivery system. Fluconazole is used for the treatment of local and systemic fungal infection. But one of the major problems for efficient drug delivery is low penetration rate of fluconazole due to its high solubility and low permeability. The hydrogel of fluconazole was prepared by cold method and evaluated. Gel was evaluated for their clarity, pH, viscosity, spreadability, studies using standard procedure. In vitro release of GF5 formulation was higher than the marketed gel. Based on r2 the GF5 formulation followed Higuchi model for the mechanism of drug release.

Keywords: Antifungal activity, Hydro gel, Fluconazole


[Full Text Article]