Abstract

INCREASED THE DISSOLUTION RATE AND SOLUBILITY OF CLOPIDOGREL BISULFATE ORODISPERSIBLE TABLETS

Ritu Sahu*, Swati Saxena, Dr. Sarang Jain

Rajeev Gandhi college of Pharmacy, Bhopal, India, 462042

ABSTRACT

The purpose of the present investigation was to increase the solubility and dissolution rate of clopidogrel bisulphate orodispersible tablets by optimization of drug: polymer ratio. Solid dispersions formulated to improve solubility & dissolution rate of poorly soluble drug clopidogrel bisulfate by physical mixture method. The prepared solid dispersions were characterized by solubility determination, drug content, and in vitro dissolution stability studies. The results revealed that solid dispersions shown improvement in solubility and dissolution characteristics than the physical mixtures and pure drug. The reasons for increase in solubility and dissolution rate is decrease in particle size, increased surface area, amorphous state of the drug in solid dispersions, absence of aggregation and increased wetting of drug molecules. Formulation F7 was selected for optimization. The drug release of optimized formulation follows the Higuchi kinetic model, and the mechanism is found to be non‐Fickian/anomalous according to Korsmeyer–Peppas. First order was maximum i.e. 0.997 hence indicating drug release from formulation was found to follow First order release kinetics.

Keywords: Orodispersible tablets, Clopidogrel bisulfate, Solid dispersions, Solubility, Dissolution rate.