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Abstract

IN VIVO ANTI INFLAMMATORY AND ANTIMICROBIAL EFFECT OF EXTRACT OF HERBAL PLANT SWERTIA CHIRATA L.

Premlata Kumari1, Vijeta Rajoria1&2, Dr. Alok pal Jain1

1RKDF College of pharmacy, Bhopal
2School of Pharmacy, Sai Nath University, Ormanjhi, Racnchi

ABSTRACT

Inflammation is a reaction of a living vascularised tissue to an injury. Conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes has serious side effects. So, number of herbal medicines is recommended for the treatment of inflammation that has no side effects. Hence our study focused to investigate the phytochemical analysis, quantification of bioactive compounds, in vitro antimicrobial activity and anti-inflammatory activity (Carrageenan-induced paw edema model) of hydroalcoholic extract of aerial parts of Swertia chirata which has boundless medicinal properties. Qualitative analysis of various phytochemical constituents, quantitative analysis of total phenolics (Folins ciocalteau reagent method) and flavonoids (Aluminium chloride method), and in vitro antimicrobial activity were determined by the well-known test protocol available in the literature. For anti-inflammatory activity, wistar albino rats were used and divided into four groups of six animals each group and Group 1 was treated as manage (formalin (0.2 ml of 2% v/v freshly prepared formalin resolution in distilled water), group 2 was received diclofenac sodium 30mg/kg, p.o. group 3 were dealt with extract (100mg/kg, p.o.). group 4 were handled with extract (200mg/kg, p.o.). The thickness was measured earlier and after injecting the formalin every day at a fixed time for seven consecutive days utilizing a vernier caliper. Phytochemical analysis revealed the presence of phenols, flavonoids, carbohydrates, and saponins. The total phenolics content of hydroalcoholic extract of Swertia chirata was (0.748mg/100mg), followed by flavonoids (1.087mg/100mg). This plant also exhibits better anti-inflammatory activity. From the present observation, it is evidenced that Swertia chirata would be an effective plant for the treatment of inflammatory reactions.

Keywords: Inflammation, Swertia chirata, in vitro antimicrobial activity, carrageenan-induced paw edema model, phytochemical analysis.


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