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Abstract

DEVELOPMENT AND CHARACTERIZATION OF TRANSFERSOMES OF ITRACONAZOLE FOR EFFECTIVE TREATMENT OF FUNGAL DISEASE

Durgesh Thakre*, Swati Saxena, Dr. Sarang Jain

Rajeev Gandhi college of Pharmacy, Bhopal, India, 462042

ABSTRACT

The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may soon render outdated conventional products such as creams, ointments and gels. Several carrier systems loaded with antifungal drugs have demonstrated promising results in the treatment of skin fungal infections. The aim of the present study was to investigate the potential of transfersomal gel formulations for transdermal delivery of Itraconazole and to evaluate the effect of lipid concentration, ethanol concentration, drug concentration and stirrer time. Characterization of transfersomes performed by vesicle size, surface charge, entrapment efficiency and stability study. Characterization of transfersomes containing gel performed by the measurement of viscosity, pH measurements, drug content, extrudability study, spreadability and in vitro drug diffusion study. It was found that viscosity of prepared gel was 3240cps, % assay was 98.56±0.23, extrudability was 145g and spreadability was found that 9.85 (g.cm/sec) respectively. In vitro drug release from transfersomes was carried out using Franz diffusion cell method and found 92.23±0.21% in 12 hr. In first 30 min it was 12.25±0.32% drug release which slightly high. It was due to the release of free drug present in bag after leaching from transfersomes. Drug release from transferosomal formulation was found in very sustained and controlled manner. The prepared gel containing Itraconazole-loaded transfersomal formulation was optimized and can be use for topical preparation for its antifungal affect. The results were obtained which showed that transfersomal gel was a promising candidate for transdermal delivery with targeted and prolonged release of a drug. It also enhances skin permeation of many drugs.

Keywords: Fungal infections, Transfersomal gel, Itraconazole, Franz diffusion cell.


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