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Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF NATEGLINIDE

Raksha Malviya1, Gurdeep Singh*2, Gulfisha Shaikh1

1Department of Pharmaceutics, Oriental College of Pharmacy & Research, Oriental University, Indore (M.P.)

2Department of Pharmaceutical Chemistry, Oriental College of Pharmacy & Research, Oriental University, Indore (M.P.)

ABSTRACT

The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide. Nateglinide is a drug for the treatment of type 2 diabetes. The present study is an attempt to select best possible combination of diluents and disintegrates to formulate fast dissolving tablets of Nateglinide which disintegrates within few minutes thereby reducing the time of onset of action. A combination of super disintegrants, i.e., sodium starch glycolate (SSG) and croscarmellose sodium (CCS) were used. IR spectroscopy showed that there is no interaction of the drug with the polymer. Direct Compression method was used to formulate the tablets. All the formulations were showed the acceptable flow properties and the pre-compression parameters like Bulk density, Tapped density and Hausner ratio. The post compression parameters like Hardness, Friability, Disintegration time, Weight variation, wetting time, Dispersion time values were found to be within the IP limits. The percentage Drug content of all tablets was found to be between 97.30% - 99.23 % of Nateglinide, which is within the limit. From the results it was found that the F6 batch was found to be optimized batch and it pass all the pre-formulation parameters and evaluation results as per the IP limits.

Keywords: Nateglinide, Type 2 diabetes, wetting time, Hausner ratio, Tapped density.


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