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Abstract

FLOATING A NEW APPROACH FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Kusum Sharma, Asit Ranjan Sahu, Ankita Srivastava, Ruchi Shukla, Komal Rahevar, D.B. Meshram

Pioneer Pharmacy Degree College, Vadodara-390019, Gujarat, India.

ABSTRACT

Floating drug delivery systems provide local delivery to specific regions like stomach and proximal small intestine and shows better bioavailability, improves patient compliance by increasing the gastric residence time and controlling the drug release. They propose several advantages over conventional dosage forms. The purpose of writing this review article is to introduce the mechanism of floatation in order to attain the gastric retention. In current decades, there have been numerous attempts to overcome the barriers like short gastric residence times and unpredictable gastric emptying times. This article covers different mechanisms, factors affecting, classification and different evaluations of floating drug delivery system. It also includes the advantages, disadvantages and applications of FDDS in detail. This review also summarizes the in vitro techniques to evaluate the drug release from floating system.

Keywords: Bioavailability, Floating drug delivery system, Gastric residence time


[Full Text Article]