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Abstract

COMPATIBILITY OF ANTI-HIV DRUGS WITH EXCIPIENTS IN THE DEVELOPMENT OF NOVEL TABLET FORMULATION

Dr. Santosh Kumar Mahapatra

Gayatri College of Pharmacy, Gayatri Vihar, Jamadarpali, Sambalpur.

ABSTRACT

The objective of this study to access the compatibility study of Zidovudine with different excipients in the development of sustained release formulation by thermal and FTIR studies. Evaluate the drug excipient compatibility study like differential scanning calorimetry (DSC) and Fourier transform infrared spectrophotometer (FTIR) studies to be performed. the result of DSC study shows that there is no interaction with excipients and the results of FTIR showed that all the excipients were compatible with Zidovudine the optimized formulation. Optimized formulation to be developed with excipients and it was observed the accelerated stability study over 3 months. Overall compatibility study of excipients with zidovudine evaluated and the sustained release formulation developed using compatible excipients were found to be stable.

Keywords: Zidovudine, sustained release tablets, DSC, FTIR.


[Full Text Article]