Login

Journal Front Page

News & Events

  • April 2024 Issue delayed
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, Volume 13, Issue 2 (April 2024) Issue) schedule published on 15 April 2024 is delay due to some technical problem. It will published on 22 April 2024. Sorry for inconvenience. For other details You can vist the website http://www.ajper.com
  • Call for article for April 2024 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

ANTI-ARTHRITIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF DACTYLORHIZA HATAGIREA

Mrinal Aryan*1, C.K. Tyagi1, Hemant Kumar Sharma1, Prabhakar Budholiya1, Geeta Parkhe2

1College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore (M. P.)
2Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Dactylorhizahatagirea (D. Don) Soo (D.hatagirea) is a perennial orchid, native to the Himalayan region. This species is distributed in India, Pakistan, Afghanistan, Nepal, Tibet and Bhutan. In India, it is distributed in Jammu and Kashmir, Uttarakhand and Himachal Pradesh. Tubers of this species are supposed as a potent medicine in Leucorrhea in Traditional System of Medicine (TSM) rich source of mucilage and are used to make Salep as food and medicine, useful as expectorant and astringent. The present study was designed to investigate anti-arthritic activity of hydroalcoholic roots extract of D. hatagireain Freund’s complete adjuvant (FCA)-induced arthritis in rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total flavonoids were determined by the wellknown test protocol available in the literature. Quantitative analysis of flavonoids was carried out by aluminium chloride method. D.hatagirea was evaluated for anti-arthritic action by Freund’s adjuvant induced arthritis test in adult Albino rats (180-250gm). Rats were injected 0.1 ml of complete Freund’s adjuvant into the planter region of the left hind paw. Diclofenac sodium used as standard drug. Statistical analysis was performed using One way analysis of variance (ANOVA) followed by Dunnet’s test. P<0.05 was considered statistically significant. The hydroalcoholic extract of D.hatagirea in doses of 400 and 800 mg/kg showed 47.53% and 69.64% protection against increase in paw volume, respectively. D.hatagirea showed dose-dependent action in all the experimental models. The present study indicates that D.hatagirea has significant anti-arthritic properties.

Keywords: Arthritis, Dactylorhizahatagirea, Diclofenac sodium, Freund’s complete adjuvant, Paw volume.


[Full Text Article]