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Abstract

INVESTIGATION ON EFFECTIVENESS OF CARBOPOL BASED GEL AS ANTI-ACNE PREPARATION CONTAINING GLYCORHIZAGLABRA ROOT EXTRACTS

Mayank Tenguria*1, Nitish Rathore2, Anajali Choudhary2, and NidhiTripathi2

1 Lenience Biotech Lab, 479/9A, Saket Nagar, Bhopal
2 Department of Biotechnology &Biochemistry, Career College, Bhopal

ABSTRACT

Skin diseases are one of the common problems sometimes caused by microbial infections where most fequently due to Staphylococcus aureus, Streptococcus pyogenes, and coryneform bacteria. In case of skin diseases topical lotions, shampoos, ointments or antifungal drugs are used in general. The present study was aimed at investigation on anti-acne potential of carbopol based gels containing Glycorhizaglabraroot extracts in vitro against two common skin pathogens Staphylococcus aureus and Propionibacterium acnes. The caropole based gel was prepared with the using ethanolic extract of G. glabradefatted root powder. The antimicrobial activity of extract and gels were performed against Staphylococcus aureus (MTCC-737) and Propionibacterium acnes (MTCC-1951) by well diffusion method shows an inhibitory potential at lowest concentration of 0.25 μg/20μl in each well individual extract with a zone size of 7 mm diameter against S. aureus whereas as zone size of 12 mm diameter against P. acnes as low as at 1.0 μg/20μl concentration of extract per well. The hydroethanolic extract was reported to contain alkaloids, flavonoids, tannins, saponins and glycosides.The prepared gel containing G. glabraextractwas clear golden yellow and homogenous appearance with a pH of 7.2, 41.25 μg/ml of TPC having spreadability range of 70.84 sq. cm also posses inhibitory potential against the same test microbes. Due to the availability of active phytodrug constituents that impart pharmacological activity could be further investigated in order to commercialize such therapeutic preparations for topical use in skin cure or improvement.

Keywords: Skin diseases, Anti-Acne gel, Carbopol-940, Glycyrrhizaglabra.


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