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Salaj Khare*, Amit Jain, Deepika prajapati.

Technocrats Institute of Technology-Pharmacy Education and Research, Bhopal (M.P.)


Coriandrum Sativum family Umbelliferae is relatively reputed ayurvedic medicinal tree. The literature related to the study reveals that although exhaustive work was carried out on umbelliferone. The work has carried mainly on hepato-protective, antioxidant, and antidiabetic activity. But not much work carried on the umbelliferone for anti-ulcer. The objective of the present study is to analyze the effect of umbelliferone on ulcer induced rats by using pylorus ligation induced ulcer. The extract was evaluated for their anti-ulcer activity in Pylorus ligation induced ulcer model in male wistar rats. The significant increase in the antiulcer activity of Coriandrum sativum can be attributed to the presence of flavanoids, alkaloids and Phenols compounds. Flavanoids are among the cytoprotective materials for which antiulcerogenic efficacy has been broadly confirmed. It is suggested that, these active compounds would be able to stimulate mucus, bicarbonate and the prostaglandin secretion and counteract with the deteriorating effects of reactive oxidants in gastrointestinal lumen. So the antiulcer activity of Coriandrum sativum can be attributed to its flavanoids content material.

Keywords: Antiulcer activity, gastric ulceration, umbelliferone, coriandrum sativum, cytoprotective

[Full Text Article]