EFFECTS OF MARKETED PREPARATION OF ALLIUM SATIVUM ON STZ INDUCE HYPERGLYCEMIA IN WISTER ALBINO RATS
Nawin Kumar*, Sanjay Kumar, Narendra Patel
College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore, (M.P.)
Management of type 2 diabetes with an agent having no side effects is still a challenge for the researchers, however if the side effects are lessened & there may be a chance for reduced adverse reactions or severe side effects due to drug interaction. These interactions may be due to either any concomitant drug therapy or any dietary supplements taken together with the drugs. Allium sativum (Garlic) is used as an important medicinal & dietary supplement in Greece, India, china & Egypt from ancient time. This study revealed that a drug interaction also provides some beneficial effects. As in this study; use of vildagliptin with garlic treatment not only resulted in glycaemic control in diabetic rats but also provided beneficial hypolipidemic effects, closely related to diabetes progression. The present study has demonstrated significant hypoglycemic & hypolipidemic effects of garlic when added with standard anti-diabetic agent. Comprehensive clinical studies are desirable to verify the effectiveness of garlic either alone or in combination with other antidiabetic agent in the treatment & prevention of diabetes risk factors.
Keywords: Allium sativum, vildagliptin, hyperglycemia, hypolipidemic
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