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  • October 2018 issue published
  • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 7, Issue 4 (October Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Call for Article for January Issue
  • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 25 December, 2018 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
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  • It is to pleasure that Ajper SJIF imact facor has increse from 4.101 to 5.019. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
  • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

EFFECTS OF MARKETED PREPARATION OF ALLIUM SATIVUM ON STZ INDUCE HYPERGLYCEMIA IN WISTER ALBINO RATS

Nawin Kumar*, Sanjay Kumar, Narendra Patel

College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore, (M.P.)

ABSTRACT

Management of type 2 diabetes with an agent having no side effects is still a challenge for the researchers, however if the side effects are lessened & there may be a chance for reduced adverse reactions or severe side effects due to drug interaction. These interactions may be due to either any concomitant drug therapy or any dietary supplements taken together with the drugs. Allium sativum (Garlic) is used as an important medicinal & dietary supplement in Greece, India, china & Egypt from ancient time. This study revealed that a drug interaction also provides some beneficial effects. As in this study; use of vildagliptin with garlic treatment not only resulted in glycaemic control in diabetic rats but also provided beneficial hypolipidemic effects, closely related to diabetes progression. The present study has demonstrated significant hypoglycemic & hypolipidemic effects of garlic when added with standard anti-diabetic agent. Comprehensive clinical studies are desirable to verify the effectiveness of garlic either alone or in combination with other antidiabetic agent in the treatment & prevention of diabetes risk factors.

Keywords: Allium sativum, vildagliptin, hyperglycemia, hypolipidemic


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