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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF TRAZODONE HYDROCHLORIDE

Govinda Sahu1, Mukesh patel1, Prabhat Jain2, Arun pandey*1

1 Mittal Institute of Pharmacy, Bhopal (M.P.)
2 Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Fast dissolving dosage forms are gaining popularity in recent time, as this dosage forms requires no water for administration. Oral films dissolve rapidly along with drug in mouth and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism. Trazodone Hydrochloride (TRZ), a serotonin reuptake inhibitor antidepressant. TRZ undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate fast dissolving oral films of TRZ to overcome the limitation of bioavailability and increase patient’s compliance. In the present study oral films were prepared by solvent casting method using HPMC K15 as a film formers and PEG 400, glycerine as plasticizers and evaluated for mechanical properties, disintegration and in vitro dissolution. All formulations showed good mechanical properties and in vitro drug release. The optimized (F5) Formulation (HPMC K15, CCS and PEG 400) Exhibited drug release of 92.12% in 15 minutes which was significantly high when compared to other formulation.

Keywords: Trazodone hydrochloride, Fast dissolving oral film, Bioavailability, Mechanical properties


[Full Text Article]