DEVELOPMENT AND CHARACTERIZATION OF ACYCLOVIR LOADED LIPOSOME USING ROTARY FLASH EVAPORATION TECHNIQUE
Mansi Gupta*, Arti Vishwakarma
Technocrats Institute of technology- Pharmacy, Bhopal (M.P.) Pin- 462021, India
The objective of the present study is to form liposomal based acyclovir ointment. Acyclovir, an antiviral drug is widely used in the treatment of herpes simplex (types 1 and 2). Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitor activity against herpes simplex virus types 1(HSV-1), 2 (HSV-2) and varicellazoster virus (VZV) that occurs at epidermis. The oral bioavailability of acyclovir is low. Five formulations of liposomal carrier for Acyclovir prepared for the treatment of viral infections that is capable of delivering the drug to the specific target site by topical route by using different ratios of phospholipids and cholesterol with a desired amount of drug by rotary flash evaporation technique. and to find out the drug entrapment from the liposome's of different ratios, drug release pattern and also to find out the size distribution of liposome's of different ratios and also to increase the bioavailability and efficacy of the drug.
Keywords: Herpes Simplex Virus (HSV), Varicella-Zoster Virus (VZV), Acyclovir (ACV).
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