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Abstract

FLOATING MICROSPHERES - AN EXCELLENT APPROACH FOR GASTRIC RETENTION

Lokesh Parmar*1, Mansi Gupta1, Prabhat Jain2

1. Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.)

2. Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Floating microspheres are multiple unit drug delivery systems which are designed to obtain prolonged or controlled drug delivery to enhance bioavailability, stability and to target the drug to a specific site at a predetermined rate. A controlled drug delivery system with the prolonged residence time in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter and intra-subject variability of gastrointestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating or hydrodynamically controlled drug delivery systems are used in such applications. Gastro retentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. Such systems have more advantages over the single unit dosage forms. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres.

Keywords: Floating microspheres, Gastro Retention, Short half-life, Solvent diffusion.


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